Dual release formulation technology enables incorporating two distinct release mechanisms within a single formulation, for a pulsatile release or extended release of active pharmaceutical ingredients (APIs). This approach offers several advantages over traditional drug delivery systems, including improved therapeutic outcomes, reduced side effects, and enhanced patient compliance.
Dual-release formulation technology typically involves 2 patterns:
The formulation contains two fractions of API, in which first dose will release to start an immediate action at the designated site in GI tract followed by the second fraction which will be an extended-release pattern till 12 hrs. This kind of release pattern will reduce the dose frequency and be more patient compliant compared to conventional dosage form.
The formulation contains two fractions of API, in which first fraction will release at the designate site in the GI tract and start the pharmacological action, The second fraction of drug shall release as per design lag time (2hrs-5hrs). This kind of pulsatile delivery will maintain long-term therapeutic level of active component into body. It is a highly efficient drug delivery for diseases which follows the bio-circadian rhythm (Chronic therapy), like Hypertension, Rheumatoid arthritis, peptic ulcers etc.
By providing both immediate and extended release of the medication, dual release formulation technology ensures that patients receive an initial dose for quick symptom relief, followed by a sustained release to maintain therapeutic levels.
The extended-release component reduces the need for multiple doses throughout the day, which can improve patient adherence to prescribed treatment regimens.
By minimizing peak plasma concentrations and maintaining more stable drug levels, dual release pellet technology can help reduce the risk of side effects associated with high drug concentrations.
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