Dual Release Formulation Technology

Dual release formulation technology enables incorporating two distinct release mechanisms within a single formulation, for a pulsatile release or extended release of active pharmaceutical ingredients (APIs). This approach offers several advantages over traditional drug delivery systems, including improved therapeutic outcomes, reduced side effects, and enhanced patient compliance. The technology offers two patterns of action:

Dual Release followed by Extended-Release

The formulation contains two fractions of API, in which first dose will release to start an immediate action at the designated site in the GI tract followed by the second fraction which will be an extended-release pattern till 12 hrs. This kind of release pattern will reduce the dose frequency and be more patient compliant compared to a conventional dosage form.

Dual Release as a Pulsatile Pattern

The formulation contains two fractions of API, in which first fraction will release at the designate site in the GI tract and start the pharmacological action. The second fraction of drug shall release as per design lag time (2hrs-5hrs). This kind of pulsatile delivery will maintain long-term therapeutic level of active component into the body. It is a highly efficient drug delivery for diseases following the bio-circadian rhythm (chronic therapy) such as hypertension, rheumatoid arthritis, peptic ulcers etc.

Improved Therapeutic Outcomes
By providing both immediate and extended release of the medication, dual release formulation technology ensures that patients receive an initial dose for quick symptom relief, followed by a sustained release to maintain therapeutic levels.
Enhanced Patient Compliance
The extended-release component reduces the need for multiple doses throughout the day, which can improve patient adherence to prescribed treatment regimens.
Reduced Side Effects
By minimizing peak plasma concentrations and maintaining more stable drug levels, dual release pellet technology can help reduce the risk of side effects associated with high drug concentrations.